An Interdisciplinary Approach to Host-Pathogen Interactions in Infection

Systemic host inflammation induces stage-specific transcriptomic modification and slower maturation in malaria parasites

LIM Lansink, OP Skinner, JA Engel, HJ Lee, MSF Soon, CG Williams, A SheelaNair, CPS Pernold, P Laohamonthonkul, J Akter, T Stoll, MM Hill, AM Talman, A Russell, M Lawniczak, X Jia, B Chua, D Anderson, DJ Creek, MP Davenport

2023-08-31

Maturation rates of malaria parasites within red blood cells (RBCs) can be influenced by host nutrient status and circadian rhythm..

Population heterogeneity in Plasmodium vivax relapse risk

E Stadler, D Cromer, S Mehra, AI Adekunle, JA Flegg, NM Anstey, JA Watson, CS Chu, I Mueller, LJ Robinson, TE Schlub, MP Davenport, DS Khoury

2022-12-01

A key characteristic of Plasmodium vivax parasites is their ability to adopt a latent liver-stage form called hypnozoites, able to..

Parasite Viability as a Measure of in Vivo Drug Activity in Preclinical and Early Clinical Antimalarial Drug Assessment

GFR Radohery, A Walz, C Gumpp, MH Cherkaoui-Rbati, N Gobeau, J Gower, MP Davenport, M Rottmann, JS McCarthy, JJ Möhrle, M Rebelo, C Demarta-Gatsi, DS Khoury

2022-07-01

The rate at which parasitemia declines in a host after treatment with an antimalarial drug is a major metric for assessment of ant..

Hypnozoite dynamics for Plasmodium vivax malaria: The epidemiological effects of radical cure

S Mehra, E Stadler, D Khoury, JM McCaw, JA Flegg

2022-03-21

Malaria is a mosquito-borne disease with a devastating global impact. Plasmodium vivax is a major cause of human malaria beyond su..

Reply to White and Watson

M Rebelo, JS McCarthy, DS Khoury

2021-08-15

Parasite Viability as a Superior Measure of Antimalarial Drug Activity in Humans

M Rebelo, R Pawliw, J Gower, L Webb, H Mitchell, Z Pava, RE Watts, MP Davenport, JS McCarthy, DS Khoury

2021-06-15

Background: Artemisinin derivatives are the leading class of antimalarial drugs due to their rapid onset of action and rapid clear..

Artemisinin Resistance and the Unique Selection Pressure of a Short-acting Antimalarial

DS Khoury, P Cao, SG Zaloumis, MP Davenport

2020-11-01

Resistance to the artemisinin derivatives, our most effective antimalarial drugs, has not manifest as a classical resistance pheno..

Malaria Parasite Clearance: What Are We Really Measuring?

DS Khoury, SG Zaloumis, MJ Grigg, A Haque, MP Davenport, D Cromer, M Rebelo, P Cao, JM McCaw, JA Simpson, JA Flegg, DW Wilson, NM Anstey, JS McCarthy

2020-05-01

Antimalarial drugs are vital for treating malaria and controlling transmission. Measuring drug efficacy in the field requires larg..

Plasmodium-specific antibodies block in vivo parasite growth without clearing infected red blood cells

J Akter, DS Khoury, R Aogo, LIM Lansink, A SheelaNair, BS Thomas, P Laohamonthonkul, CPS Pernold, MWA Dixon, MSF Soon, LG Fogg, JA Engel, T Elliott, I Sebina, KR James, D Cromer, MP Davenport, A Haque

2019-02-01

Plasmodium parasites invade and multiply inside red blood cells (RBC). Through a cycle of maturation, asexual replication, rupture..

Within-host modeling of blood-stage malaria

DS Khoury, R Aogo, G Randriafanomezantsoa-Radohery, JM McCaw, JA Simpson, JS McCarthy, A Haque, D Cromer, MP Davenport

2018-09-01

Malaria infection continues to be a major health problem worldwide and drug resistance in the major human parasite species, Plasmo..